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英语翻译Cartilage intermediate-layer protein (CILP)CILP is a mon

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英语翻译
Cartilage intermediate-layer protein (CILP)
CILP is a monomeric extracellular matrix glycoprotein
expressed mainly in the middle zones of human
articular cartilage and in the meniscus,tendons,ligaments,
synovial membrane,and intervertebral disc (41).
CILP acts as a negative regulator of TGF_,which
controls the expression of aggrecan,type II collagen,
and extracellular matrix proteins important in the mechanism
of fibrosis of the intervertebral disc annulus and in
maintaining nucleus pulposus integrity.Key information
about CILP is reviewed succinctly in an article by Mori
et al (41).Human articular cartilage CILP expression
increases with aging,in the early and late stages of OA,
and in calcium pyrophosphate dihydrate crystal deposition
disease.A functional SNP in CILP is associated
with susceptibility to lumbar disc disease in the Japanese
population (Table 3).This study also showed increased
localization of CILP in degenerated intervertebral disc.
Perhaps the mutant CILP protein affects chondrocyte
homeostasis by exerting an increased inhibitory effect on
TGF_1.These epidemiologic findings were not replicated
in Finnish and Chinese cohorts affected by lumbar
disc disease,which might reflect ethnic differences in the
risk factors for lumbar disc disease (Table 3).
goggle翻译的说了不行。:喵喵爱学习 我等你 别翻译外行了啊 呵呵 下午能翻译好就行!
给我一点时间 我来试试
楼上的是在线翻的吧……
完全不对头啊……
我手工去了~楼主等我
软骨的中间层蛋白(CILP)
CILP是细胞外基质糖蛋白的单体
主要表达在人体再见部位比如
关节软骨及半月板,肌腱,韧带,
滑膜,与椎间盘(41).
CILP充当着TGF_的负极调控器,与后者一起可以
控制蛋白多糖的释放,Ⅱ型胶原蛋白,
和细胞外基质蛋白这些对于保持
椎间盘的纤维环和
维持髓核的完整性起到重要作用的组织.
CILP的关键信息在Moriet所著的一篇文章中被简要提起(41).
人关节软骨CILP释放(再生?)
随着年龄的增加、骨关节炎的早期和晚期阶段、
和焦磷酸二水结晶沉积发生的钙
疾病等现象而增长.以功能性SNP的关联CILP
易感性与腰椎间盘疾病中的日本人
人口(见表3).这项研究还显示出增加
本土化的CILP椎间盘退变.
或许CILP也在影响软骨细胞蛋白突变
稳态对TGF_1施加增加的抑制作用
对芬兰和中国的流行病学研究椎间盘疾病所进行的流行病学研究却不尽相同,
这可能反映了
在治疗腰椎间盘突出症的危险因素上所体现出的种族差异(见表3)
= =好吧 我最怕翻译医学什么的了、、、还要麻烦楼主回去自己看下哪里的术语翻译不当自己改改哦~