翻译一段话求通顺In this study, we showed that midlife dietary fat in

翻译一段话求通顺
In this study, we showed that midlife dietary fat intake
was related to cognitive performance, especially in
domains of global cognitive function, semantic memory
and psychomotor speed, and to the occurrence of MCI
later in life. To our knowledge, this is the first study to
investigate the association between midlife dietary fat
intake and later cognitive performance. These results are
in accordance with some earlier shorter term follow-up
studies suggesting that dietary saturated fats may have
negative effects, whereas unsaturated fats may have
positive effects on cognition (Kalmijn et al., 1997a;
Morris et al., 2004; Morris et al., 2005).
Our results agree with one earlier study that diet
may have a stronger effect on cognitive function
among women (Lee et al., 2001). The sex differences
in lipid metabolism may partly explain the divergent
results (Mittendorfer, 2005), but also men in this
region tended to die prematurely from cardiovascular
disease (Puska et al., 1983).
In earlier studies higher SFA intake (Laitinen et al.,
2006), and higher energy intake (Luchsinger et al.,
2002) seemed to be associated with a higher risk of
AD especially among the ApoE e4 allele carriers. It
has been previously proposed that the effect of dietary
fats on the lipid and lipoprotein metabolism may differ
by ApoE allele status (Rubin and Berglund, 2002). In
this study, we did not observe any significant ‘e4-SFA’
–interactions.
The mechanisms by which dietary fats may affect
cognitive performance are unknown, but several
hypothetical pathways have been proposed. Vascular
factors might be important mediators as they may lead
to impaired cognitive function through white matter
lesions (Breteler et al., 1994). In our study adjustment
for several cardiovascular risk factors and diseases,
however, did not attenuate the results. Diet high in fat/
SFA may lead to cognitive impairment also through its
effects on for example hyperinsulinemia (Greenwoodand Winocur, 2005), oxidative stress (Zhang et al.,
2005), or endothelial damage (Roberts et al., 2005).
Alterations in the body fat could disregulate estrogen
balance and lead to cognitive changes (Gibbs and
Gabor, 2003). The effect may also be conveyed by
inflammatory mechanisms (James et al., 2000).
Further, in experimental studies SFAs have decreased
the levels of hippocampal brain-derived neurotrophic
factor (BDNF) that are relevant for neuronal plasticity
and the maintenance of cognitive functions (Molteni
et al., 2002). Diet high in SFA and cholesterol may
increase hippocampal accumulation of amyloid betapeptide
(Ab) (Oksman et al., 2006).

本次研究表明,中年饮食中的脂肪摄入量与人的认知活动有关,尤其在如下的领域：整体认知功能,语义记忆,思维速度和后天生活的MCI活动等等.据我们所知,这是针对中年脂肪摄入与后天认知活动关系的首次研究.这次结果与之前持续的研究结论不谋而合,即食物中的饱和脂肪可能对思维认知有消极作用,而不饱和脂肪则可能有积极作用.
我们的结果与之前的研究结果相似,相对于男性,女性的饮食活动可能对认知功能有更强的作用效果.类脂物代谢作用方面的性别的差异可能有助于解释这一分歧,而且这一方面,男性更有可能因为心血管疾病早逝.
早期的试验中,愈多的SFA和能量摄入似乎与更高的AD风险相连.特别是在ApoE e4 等位基因的携带者当中.食物脂肪作用于脂肪代谢和蛋白质代谢的效果可能因ApoE等位状况而迥异,这一点早有说明(Rubin and Berglund,2002).我们的研究并没有发现任何有用的‘e4-SFA’相互作用.
食物脂肪可能影响认知活动的机理尚属未知,但是几条假定路径已被提及.血管因子可能是重要的媒介,因为它们通过白质损伤降低认知功能(Breteler et al.,1994).我们的研究基于几类心血管危险性因素和疾病做了相关调整,但是,我们的结果并没有因为这些调整改变.高脂肪的食物也可能通过它对高胰岛纤维蛋白(Greenwoodand Winocur,2005),oxidative stress (Zhang et al.,2005)或者内皮损伤(Roberts et al.,2005)的作用来降低认知.体内脂肪的变动也许会导致雌激素紊乱和思维认知的变化(Gibbs and Gabor,2003).其作用效果也可以通过刺激性的方法来演示(James et al.,2000).另外,实验性研究中,SFA降低了取自海马趾大脑的向神经因子的水平.这些向神经因子与神经元的可塑性及认知功能的维持颇有关联(Molteniet al.,2002).高脂肪、高胆固醇的饮食可能增加淀粉样β肽的海马趾积累(Oksman et al.,2006).
大致就这样了,其中很多你们的术语需要仔细修改,因为我很不了解.