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下句中Itch-mediated 和Itch?生物学文献中的.网上都查过了,好像都不合适.

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下句中Itch-mediated 和Itch?生物学文献中的.网上都查过了,好像都不合适.
原句是In contrast to TNFa plus cycloheximide no cFLIP degradation is observed suggesting a different apoptosis pathway in which the Itch-mediated cFLIP degradation and predominantly caspase-8 activation is not involved.和It has been reported that JNK directly activates the E3 ubiquitin ligase Itch which induces proteasomal processing of cFLIP
have a strong desire or urge to do something; "She is itching to start the project"; "He is spoiling for a fight"应该是一个增强语气的一个吃,重点强调后面的mediate