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英语翻译Ligands of the transforming growth factor-beta (TGF beta

来源:学生作业帮 编辑:作业帮 分类:英语作业 时间:2024/05/23 17:52:09
英语翻译
Ligands of the transforming growth factor-beta (TGF beta) superfamily of growth factors initiate signal transduction through a bewildering complexity of ligand-receptor interactions.Signalling then converges to nuclear accumulation of transcriptionally active SMAD complexes and gives rise to a plethora of specific functional responses in both embryos and adult organisms.Current research is focused on the mechanisms that regulate SMAD activity to evoke cell-type-specific and context-dependent transcriptional programmes.An equally important challenge is understanding the functional role of signal strength and duration.How are these quantitative aspects of the extracellular signal regulated?How are they then sensed and interpreted,and how do they affect responses?
就这段.是一片名为"TGF beta-SMAD signal transduction:molecular specificity and functional flexibility"的文献的摘要..请不要用在线翻译直接翻译.
生长因子中TGF-β超家族的配体通过一种复杂的配体受体互作方式来转导信号.无论在胚胎还是成人组织中,信号都会传导至在细胞核中积累的具有转录活性的SMAD复合体,然后激发相对应的功能性回应.目前的研究工作聚焦在SMAD活性调节的机制,这种调节过程造成了细胞类型特异性的和依赖于具体环境的转录过程.另一个同样重要的挑战是弄清楚信号强度和持续时间在这些过程中的功能性作用,像如何调控胞外信号的这两个定量指标?它们又是如何被细胞感知和识别,以及影响细胞回应过程的?
翻译不难,楼主该补习外语了.