英语翻译Insulin signaling and dietary restriction differentially

英语翻译
Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.
Abstract:Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and memory are unknown. Here we show that the C. elegans Insulin/IGF-1 receptor mutant daf-2 improves memory performance early in adulthood and maintains learning ability better with age but, surprisingly, demonstrates no extension in long-term memory with age. By contrast, eat-2 mutants, a model of Dietary Restriction (DR), exhibit impaired long-term memory in young adulthood but maintain this level of memory longer with age. We find that crh-1, the C. elegans homolog of the CREB transcription factor, is required for long-term associative memory, but not for learning or short-term memory. The expression of crh-1 declines with age and differs in the longevity mutants, and CREB expression and activity correlate with memory performance. Our results suggest that specific longevity treatments have acute and long-term effects on cognitive functions that decline with age through their regulation of rate-limiting genes required for learning and memory.
只会用工具翻译得读都读不通的就不要浪费力气了 翻译的好的有加分哦

胰岛素信号和忌口对年长人群学习和记忆能力退化的不同影响
摘要：记忆减退是最具毁灭性的年龄退行性缺陷的一种.虽然科学家已经研究出延长寿命的方法,但是随着寿命增长提高学习和记忆的方法还没发现.在此篇文献中,我们发现 C.elegans Insulin/IGF-1 受体的突变体daf-2 有助于在成人期的早期提高记忆水平并且在老年之后保持较好的学习能力,但是无法在在老年之后提高长期记忆能力.与之相对,eat-2 变异的忌口模型会使成人期长期记忆受损,但是可以在老年期保持很高的长期记忆水平.我们还发现作为CREG的转录因子的C.elegans的同族物-——crh-1——在长期记忆中发挥很大的作用,但是在学习和短期记忆过程中作用微弱.crh-1随着年龄增加其表达会减少,这一过程同长寿变异不同.CREB的表达和活性同记忆水平有关.本篇实验的结果表明,通过调节学习和记忆相关的限速基因从而增加寿命这一过程在实验体老年时会对其认知功能急性和长期的下降.
又是一个跟神经有关的.