英语翻译在艾滋病的外文文献中一直出现的.那viral fitness呢？

英语翻译
在艾滋病的外文文献中一直出现的.
那viral
fitness呢？

circulate是传播,co-circulate 共同传播
供你参考,
Viral fitness ：病毒适应性
给你找到一片类似文章,供你参考,
Treatment of HIV/AIDS with antiretroviral therapy can result in HIV-1 drug resistance,limiting its use.Resistance mutations arise prior to therapy due to errors in HIV-1 replication,and are also spread by sexual and other modes of transmission.However,it is also generally believed that resistance is due to multiple drug mutations to any single or combination of antiretroviral agents selected during viral replication in the presence of incompletely suppressive drug regimens.In the case of protease inhibitors and most nucleoside analog reverse transcriptase inhibitors,drug resistance is due to the accumulation of mutations in the HIV-1 protease and reverse transcriptase genes respectively.However,in the case of non-nucleoside reverse transcriptase inhibitors,a single primary drug mutation is usually sufficient to abrogate antiviral activity.This is also true of certain specific mutations,such as M184V in the reverse transcriptase enzyme,resulting in resistance to the nucleoside analog,lamivudine (Epivir®,GlaxoSmithKline).However,it is thought that lamivudine may still contribute to the effectiveness of antiretroviral therapy,even after the appearance of the M184V mutation.M184V may affect sensitivity to other drugs,such as zidovudine (Retrovir®,GlaxoSmithKline),in HIV-1 variants that already contain resistance mutations to zidovudine,during concomitant treatment with lamivudine.M184V also has a positive effect on HIV-1 RT fidelity,reducing spontaneous HIV mutagenesis.Processivity of the reverse transcriptase enzyme may be affected by mutations such as M184V,and this may be a major determinant of viral replication fitness.
翻译后摘要:抗逆转录病毒治疗的艾滋病毒/艾滋病的治疗,可能会导致在HIV-1耐药性,限制了它的使用.出现耐药突变前治疗HIV-1复制中的错误,也被性暴力和其他传播方式传播.但是,它也普遍认为电阻是由于多种药物突变任何单一或组合的病毒复制过程中选择的抗逆转录病毒药物的存在下不完全抑制的药物治疗方案.蛋白酶抑制剂和核苷类似物逆转录酶抑制剂的情况下,耐药性是由于在HIV-1蛋白酶和逆转录酶基因突变的积累.然而,在非核苷类逆转录酶抑制剂的情况下,一个单一的主药突变通常是足够废除的抗病毒活性.某些特定的突变,如在逆转录酶M184V,导致耐核苷类似物,拉米夫定（度Epivir®,葛兰素史克）,这也是真实的.但是,它被认为拉米夫定仍可能有助于抗逆转录病毒治疗的有效性,即使在外观M184V突变.M184V可能会影响其他药物,如齐多夫定（多夫®,葛兰素史克）的敏感性,在HIV-1的变种,已经包含了齐多夫定,在与拉米夫定联合治疗的耐药突变.,M184V也对HIV-1逆转录酶的保真度有着积极的作用,减少艾滋病毒自发突变.如M184V突变的逆转录酶的持续合成可能受到影响,这可能是一个主要决定因素,病毒复制的健身.